Borrelia burgdorferi Host

Neurological manifestations of Lyme disease in humans are attributed in part to penetration of the blood-brain barrier (BBB) and invasion of the central nervous system (CNS) by Borrelia burgdorferi However how the spirochetes cross the BBB remains an unresolved issue We examined the traversal of B burgdorferi across the human BBB and systemic endothelial cell barriers using in vitro model

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Blood Brain Barrier

Although many new drugs are being developed to combat these and other brain diseases few new treatments have made it to the clinic The impermeable nature of the brain vasculature also known as the blood-brain barrier (BBB) is at least partially responsible for the paucity of new brain therapeutics

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FDA prescribing information side effects and uses

Drugs provides accurate and independent information on more than 24 000 prescription drugs over-the-counter medicines and natural products This material is provided for educational purposes only and is not intended for medical advice diagnosis or treatment Data sources include IBM Watson Micromedex (updated 4 May 2020) Cerner Multum™ (updated 2 June 2020) Wolters Kluwer™

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Drugs which cross Blood Brain Barrier

The blood-brain barrier is an effective way to protect the brain from common infections Thus infections of the brain are very rare however as antibodies are too large to cross the blood-brain barrier when infections of the brain do occur they can be very serious and difficult to treat By three methods drugs cross

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Drug Distribution to Tissues

17 06 2020Blood-brain barrier Drugs reach the central nervous system (CNS) via brain capillaries and cerebrospinal fluid (CSF) Although the brain receives about one sixth of cardiac output drug penetration is restricted because of the brain's permeability characteristics

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DRUG DELIVERY ACROSS THE BLOOD

Abstract Drug delivery to the brain is a process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies However the Blood brain barrier formed by brain capillary endothelial cells constitutes a major obstacle for drug entry into the central nervous system Various strategies have been developed to

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Blood

The idea of Blood Brain Barrier (BBB) dates back to more than 100 years ago when Paul Erlich observed that by intravenous injection of certain dyes all organs of the animal body were stained except the brain and the spinal cord The densely packed brain endothelial cells are the main part of BBB which are surrounded by astrocytic end feet lumen and pericyte cells This barrier protects

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The Blood–Brain Barrier

The blood–brain barrier (BBB) is a term used to describe the unique properties of the microvasculature of the central nervous system (CNS) CNS vessels are continuous nonfenestrated vessels but also contain a series of additional properties that allow them to tightly regulate the movement of molecules ions and cells between the blood and the CNS ( Zlokovic 2008 Daneman 2012 )

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Blood Brain Barrier

The blood-brain barrier presents difficulties in the chemotherapy of brain diseases because drugs that could enter other organs may not be able to enter the brain In the treatment of Parkinson 's disease for example patients who need a chemical called dopamine in the brain are often given a precursor molecule called levodopa (L-dopa) because L-dopa can cross the blood-brain barrier but

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Blood–brain barrier: Definition structure function

Blood–brain barrier Author: Lorenzo Crumbie MBBS BSc • Reviewer: Jerome Goffin • Last reviewed: June 15 2020 The brain is the epicentre of an eclectic array of physiological activity It integrates information from the external environment with signals from the internal environment in order to execute specific activities

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Characteristics of compounds that cross the blood

12 06 2009Substances cross the blood-brain barrier (BBB) by a variety of mechanisms These include transmembrane diffusion saturable transporters adsorptive endocytosis and the extracellular pathways Here we focus on the chief characteristics of two mechanisms especially important in drug delivery: transmembrane diffusion and transporters

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DRUG DELIVERY ACROSS THE BLOOD

The introduction of the present article talks about main three points: A major difficulty in treatment many central nervous system related diseases the percentage of different molecules drugs that do not cross the blood-brain barrier and related approached developed in the last decade The delivery of therapeutic agent to the brain has been a major difficulty in treatment may central nervous

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Nanoparticles Designed to Cross Blood

This barrier also keeps out drugs to treat neurological conditions such as Parkinson's or Alzheimer's disease and its impaired functioning is also implicated in these disorders So far no efficient method is available to penetrate this barrier preventing some 98 percent of current drugs from reaching the brain or central nervous system

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A New Blood

Blood-brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the neurovascular unit While pericytes are the cells situated closest to brain endothelial cells morphologically and share a common basement membrane they have not been used in co-culture BBB models for testing drug permeability We have

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Blood Brain Barrier Model

6 Current Blood Brain Barrier Models: Current testing of pharmacological products ability to cross the blood brain barrier is primarily done in in vitro bioreactor systems The use of in vivo systems has occurred however most systems used are in vitro systems The use of in vitro bioreactors allows for critical testing of drugs and the exclusion of drugs that would be selected against by the

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Clonidine Transport at the Mouse Blood—Brain Barrier by

Identifying drug transporters and their in vivo significance will help to explain why some central nervous system (CNS) drugs cross the blood-brain barrier (BBB) and reach the brain parenchyma We characterized the transport of the drug Clonidine at the luminal BBB by in situ mouse brain perfusion Clonidine influx was saturable followed by Michaelis–Menten kinetics (K m = 0 62 mmol/L V

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Multifunctional Nanocarriers for diagnostics drug

We highlight the leading advantage of nanocarriers i e their ability to cross the blood-brain barrier (BBB) a tightly packed layer of endothelial cells surrounding the brain that prevents high-molecular weight molecules from entering the brain The BBB has several transport molecules such as growth factors insulin and transferrin that can potentially increase the efficiency and kinetics of

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Nanoparticles Designed to Cross Blood

This barrier also keeps out drugs to treat neurological conditions such as Parkinson's or Alzheimer's disease and its impaired functioning is also implicated in these disorders So far no efficient method is available to penetrate this barrier preventing some 98 percent of current drugs from reaching the brain or central nervous system

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The blood

The blood-brain barrier: Structure function and therapeutic approaches structure of the BBB and the different procedures utilized currently and those proposed to cross it Chemical modifications of the drugs such as increasing their lipophilicity Characteristics of the BBB ECs

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