MRI of Articular Cartilage: Revisiting Current Status and

Articular cartilage plays an essential role in the function of the diarthrodial joints of the body but is frequently the target of degeneration or traumatic injury The recent development of several surgical procedures that hold the promise of forming repair tissue that is hyaline or hyalinelike cartilage has increased the need for accurate noninvasive assessment of both native articular

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Articular Cartilage Injuries : A Publication of The

The articular cartilage ECM consists of water and a macromolecular framework formed primarily by collagens and large aggregating PGs 24 The collagens give the tissue its form and tensile strength and the interaction of aggregating PGs with water give the tissue its stiffness to compression resilience and probably its durability Loading of articular surfaces causes movement of fluid within

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Advances in articular cartilage defect management

Articular cartilage has only a single type of cell for renewal — the chondrocyte — which becomes less active with age and injury While long-term research goals focus on harnessing stem cell therapies for renewal in the near term Mayo Clinic orthopedists choose from multiple treatment strategies to manage cartilage injuries Three Mayo Clinic orthopedic innovations in cartilage-defect

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NFIA and GATA3 are crucial regulators of embryonic

However articular cartilage-specific ablation of Erg does not affect embryonic articular cartilage differentiation but leads to osteoarthritis-like phenotypic defects in 11-month-old mice (Ohta et al 2015) c-Jun presumably owing to its ability to promote transcription of the Wnt ligands Wnt9a and Wnt16 is necessary for articular cartilage differentiation (Kan and Tabin 2013) However

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Cartilage

Mechanical Behaviour of Articular Cartilage The mechanical behaviour depend on interaction of its component : proteoglycan collagen and interstitial fluid In an aqueous environment proteogylcans are polyanionic which means the molecule has negatively charged sites that arise from sulfate and carboxyl In solution the mutual repulsion of these negative charges causes the aggregated

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Biochemical changes in knee articular cartilage of novice

T2 relaxation time mapping has been validated as a tool for analyzing changes in articular cartilage water content and collagen array with elevated values representing increased water content and loss of cartilage anisotropy 12 –14 Research has shown that T2 mapping sequences could effectively identify healthy and early-stage osteoarthritis cartilage 13 15 A previous MRI assessment

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Articular cartilage and changes in Arthritis: Cell biology

Chondrocytes of articular cartilage produce and retain significant amounts of active and inactive BMPs known to increase extracellular matrix synthesis and induce chondrogenesis and osteogenesis For example both normal and OA chondrocytes synthesize and

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Articular cartilage: from formation to tissue engineering

While articular cartilage was predicted to be one of the first tissues to be successfully engineered it proved to be challenging to reproduce the complex architecture and biomechanical properties of the native tissue Despite significant research efforts only a limited number of studies have evolved up to the clinical trial stage This review article summarizes the current state of cartilage

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Articular Cartilage Research Group

Articular Cartilage Research group: New protocols to cryopreserve different sizes of articular cartilage for future transplantation Other joint reconstruction relate research Example from Ron Moore's group - Urology Kidney Oncology Transplantation Research Group: New therapies to reduce the need to remove urological organs and clinical analysis of kidney transplantation

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NFIA and GATA3 are crucial regulators of embryonic

However articular cartilage-specific ablation of Erg does not affect embryonic articular cartilage differentiation but leads to osteoarthritis-like phenotypic defects in 11-month-old mice (Ohta et al 2015) c-Jun presumably owing to its ability to promote transcription of the Wnt ligands Wnt9a and Wnt16 is necessary for articular cartilage differentiation (Kan and Tabin 2013) However

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Articular Cartilage

Articular Cartilage and Menisci Movement of the bones causes friction between the articulating surfaces To reduce this friction all articulating surfaces involved in movement are covered with a white shiny slippery layer called articular cartilage The articulating surface of the femoral condyles tibial plateaus and the back of the patella are covered with this cartilage The cartilage

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Radiographic Findings of Osteoarthritis versus

A system for grading articular cartilage lesions at arthroscopy Am J Sports Med 1989 17:505–513 Crossref Medline Google Scholar 12 Altman RD Hochberg M Murphy WA Jr Wolfe F Lequesne M Atlas of individual radiographic features in osteoarthritis Osteoarthritis Cartilage 1995 3(suppl A):3–70 Medline Google Scholar

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Lubrication of articular cartilage

Indeed the articular cartilage layers that coat the ends of the bones and slide past each other as we flex our joints are the most efficiently lubricated surfaces in nature No manmade material can match the ultralow sliding friction which is a consequence of the lubrication that cartilage provides at the high pressures and low velocities that our joints experience Such low friction is

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Intra

Osteoarthritis (OA) is characterised by loss of articular cartilage which is associated with clinical outcomes including knee replacement 1 2 Whereas current treatments alleviate symptoms without targeting structural progression 3 disease-modifying OA drugs (DMOADs) aim to modify tissue structure such as articular cartilage ideally in conjunction with improving clinical outcomes 4 5 No

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Articular Cartilage Injury

Articular cartilage is a complex living tissue that lines the bony surface of joints It provides a low-friction surface enabling the joint to withstand weight-bearing movements both for daily activities as well as athletics including walking and stair climbing and work-related activities In other words articular cartilage is a very thin shock absorber Articular cartilage injuries can

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Cartilage Health

Articular cartilage has been known to be a potential problem for quite a while! In Roman times after gladiators had 'dissected' each other fighting their physician Galen witnessed human tendons cartilage and ligaments and made the observation that "athletes get arthritis" 250 years ago a famous anatomist noted that "ulcerated cartilage is a troublesome thing and once

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Study of Safety Tolerability Preliminary Efficacy of

Patient has a symptomatic single articular cartilage defect of one knee grade II or IIIA according to the ICRS classification localized to either the femoral condyles/femoral trochlea or to the patella based on MRI or arthroscopy performed within 9 months before screening visit and confirmed by screening 3T MRI Patient has an onset of pain and impairment of function between two (2

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Management of Articular Cartilage Defects of the Knee

Articular cartilage has a poor intrinsic capacity for healing The goal of surgical techniques to repair articular cartilage injuries is to achieve the regeneration of organized hyaline cartilage Microfracture and other bone marrow stimulation techniques involve penetration of the subchondral plate in order to recruit mesenchymal stem cells into the chondral defect The formation of a stable

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Blue Histology

Draw the articular cartilage at low magnification Indicate in your drawing the preferred orientations of lacunae and isogenous groups and the expected orientation of collagen fibres Degeneration and Regeneration of Cartilage Due to the fairly poor access of nutrients to the chondrocytes they may atrophy in deep parts of thick cartilage Water content decreases and small cavities arise in

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Articular cartilage damage

Articular cartilage is usually found in layers of between 2 and 4 mm thick As with all types of cartilage the absence of blood vessels and lymph vessels creates a very slow metabolic environment Chondrocyte proliferation and apoptosis (death) exists at much lower rates than in noncartilagenous connective tissue Low levels of oxygen mean chondrocytes primarily depend upon anaerobic

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What's New in Cartilage Repair

Articular cartilage lines the ends of our joint surfaces and is composed of cells called chondrocytes with a matrix or scaffolding made of collagen and proteins In healthy joints this unique and durable material allows bones to move against one another with minimal friction Figure 1 (Left): View of a normal knee joint through an arthroscope showing smooth articular cartilage and the

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Materials

Articular cartilage lesions (ACL) were created at the femoropatellar groove in rat knees and cell free collagen I-based scaffolds (S) were then implanted into right knee defect for the ACL-S group No scaffold was implanted for the ACL group At 4- 8- and 16-weeks post-transplantation degrees of cartilage repair were evaluated by morphological histochemical and gene expression analyses

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